Neurons in Alzheimer’s disease patients tend to re-enter the cell cycle and quickly progress to senescence. Using advanced snRNA-seq techniques, researchers analyzed over 30,000 nuclei to track these changes, finding that these neurons often fail to complete the cell cycle and instead show signs of aging.
A new study reveals a biological link between enjoying nature and reduced inflammation levels, which could help in preventing or managing chronic inflammation-related diseases like heart disease and diabetes. The study analyzed data from the Midlife in the U.S. (MIDUS) survey, focusing on 1,244 participants, and found that frequent positive interactions with nature correlated with […]
Researchers are pioneering the use of artificial intelligence to explore how the gut microbiome influences Alzheimer’s disease. Their latest study employs AI to analyze how metabolites produced by gut bacteria interact with cellular receptors, potentially contributing to Alzheimer’s development.
Socioeconomic status, lifestyle, and psychological factors significantly influence the development of chronic musculoskeletal pain after injury. The study found that individuals from lower socioeconomic backgrounds are twice as likely to experience chronic pain, and those with additional risk factors such as smoking, fear of movement, and poor support networks are up to seven times more […]
Researchers made a significant discovery in understanding the mechanisms behind protein accumulation in neurodegenerative diseases like Alzheimer’s. By studying fruit flies, the team found that a reduction in mitochondria within neuron axons leads directly to this detrimental protein buildup.
A new study revealed significant risks associated with antipsychotic use in dementia patients, including increased chances of stroke, heart failure, pneumonia, and other serious conditions. The research analyzed data from 173,910 dementia patients in England, tracking those prescribed antipsychotics post-diagnosis against those who were not.
Cnicin, a compound derived from the plant Blessed Thistle, significantly enhances nerve regeneration. The study shows that Cnicin can accelerate the growth of axons, the long fibers of nerve cells, which is crucial for the recovery of nerve function after injury.
Researchers initiated a pioneering clinical trial using an advanced form of CAR-T therapy, enhanced by synthetic notch (synNotch) technology, to treat glioblastoma. This trial represents a significant shift towards targeted, safer cancer therapies.
Optical coherence tomography, commonly used in eye exams, can monitor neurodegeneration in Parkinson’s disease patients by measuring the thickness of the retina. This method has revealed that retinal degeneration often precedes cognitive and motor decline, offering a potential early indicator of disease progression.
Researchers identified a specific pattern of autoantibodies in the blood that precedes the clinical onset of multiple sclerosis (MS), potentially paving the way for early diagnosis and treatment. Their study found that 10% of MS patients displayed a unique set of autoantibodies against both human proteins and common pathogens like the Epstein-Barr Virus years before […]